Which hormonal therapy is known to cause hot flashes and increase liver function tests (LFTs)?

Which hormonal therapy is known to cause hot flashes and increase liver function tests (LFTs)?

• A. Tamoxifen (Soltamox)
• B. Fulvestrant (Faslodex)
• C. Leuprolide (Lupron)
• D. Goserelin (Zoladex)

Answer: (B)

Fulvestrant, commonly known by its brand name Faslodex, is a selective estrogen receptor down regulator (SERD) used primarily in the treatment of hormone receptor-positive breast cancer. One of the notable side effects associated with fulvestrant is the occurrence of hot flashes. This is a common symptom experienced by patients undergoing hormonal therapy, especially in those whose treatments affect estrogen levels in the body. In addition to the phenomenon of hot flashes, fulvestrant has been reported to have an impact on liver function tests (LFTs). Monitoring of liver enzymes is essential while patients are on this medication, as increases in liver function tests can indicate liver toxicity or impairment, necessitating further evaluation or potential modification of therapy. While other hormonal therapies listed may have their own side effects, including effects on the endocrine and reproductive systems, fulvestrant stands out for both the hot flashes and the potential impact on liver function, which aligns with what is specifically mentioned in the question. This makes it the most relevant choice among the options provided.

Fulvestrant, commonly known by its brand name Faslodex, is a selective estrogen receptor down regulator (SERD) used primarily in the treatment of hormone receptor-positive breast cancer. One of the notable side effects associated with fulvestrant is the occurrence of hot flashes. This is a common symptom experienced by patients undergoing hormonal therapy, especially in those whose treatments affect estrogen levels in the body.

In addition to the phenomenon of hot flashes, fulvestrant has been reported to have an impact on liver function tests (LFTs). Monitoring of liver enzymes is essential while patients are on this medication, as increases in liver function tests can indicate liver toxicity or impairment, necessitating further evaluation or potential modification of therapy.

While other hormonal therapies listed may have their own side effects, including effects on the endocrine and reproductive systems, fulvestrant stands out for both the hot flashes and the potential impact on liver function, which aligns with what is specifically mentioned in the question. This makes it the most relevant choice among the options provided.